Neuroscience Research Compound · For laboratory research use only
Also known as Bromantan
Bromantane (N-(4-bromophenyl)adamantan-2-amine), also written bromantan, is an adamantane derivative developed in Russia. It is described in the pharmacological literature as an actoprotector, a class of synthetic compounds studied for stability against physical load5.
Most of the published work comes from Russian laboratories and is preclinical, and a large part of it appears in Russian-language journals. Studies have examined catecholamine biosynthesis and hippocampal synaptic plasticity in rats, gene expression in rat brain regions, inflammatory cytokines in a mouse model, and reproductive and developmental endpoints in rats1,2,3,4,6.
As described in the research literature
As described in the research literature, a single exposure in rats was associated with region-specific changes in tyrosine hydroxylase mRNA and protein, and in dopamine and L-DOPA content, across the ventral tegmental area, nucleus accumbens, hypothalamus, striatum and hippocampus1. In rat hippocampal slices, application of the compound converted short-term potentiation of synaptic transmission into a long-lasting form; this was blocked by the protein synthesis inhibitor anisomycin and attenuated by the D1/D5 receptor antagonist SCH233901.
Work from the same research network examined how tyrosine hydroxylase transcription might be regulated. Bisulfite sequencing of the 5'-flanking region of the tyrosine hydroxylase gene in rat hypothalamus cells showed more frequent cytosine demethylation at or near transcription factor binding sites after a single exposure2. A further study measured ERK1/ERK2 content and phosphorylation, and NGF and BDNF gene expression, in rat striatum, hypothalamus and hippocampus3.
What published studies have examined
Rat studies measured tyrosine hydroxylase mRNA and protein, dopamine and L-DOPA in five brain regions, and examined activity-dependent synaptic plasticity in hippocampal slices, including its dependence on protein synthesis and D1/D5 receptors1. Epigenetic regulation of the tyrosine hydroxylase promoter in the hypothalamus was examined separately2.
Studies from the same research network examined promoter methylation of the tyrosine hydroxylase gene2 and the expression of neurotrophin genes (NGF and BDNF) together with the mitogen-activated kinases ERK1/ERK2 in several rat brain regions3.
In male C57Bl/6 mice given bacterial lipopolysaccharide to induce a depression-like state, plasma TNF-alpha, IL-6 and eight other cytokines were measured alongside behaviour, comparing the compound with imipramine and controls4.
Sources [4]
A 2012 review describes the history, pharmacological properties and proposed mechanisms of actoprotectors, with bemitil and bromantane as the main representatives of the class5. A rat study examined gestation, litter size, offspring maturation, reflex development and open-field behaviour after female rats were treated before mating6.
The effects of ladasten on dopaminergic neurotransmission and hippocampal synaptic plasticity in rats.
Mikhaylova M, Vakhitova JV, Yamidanov RS, et al. Neuropharmacology, 2007.
[Cytosine demethylation in the tyrosine hydroxylase gene promoter in the hypothalamus cells of the rat brain under the action of an aminoadamantane derivative Ladasten].
Vakhitova IuV, Sadovnikov SV, Iamidanov RS, et al. Genetika, 2006.
Mechanisms of action of ladasten: activation of gene expression for neurotrophins and mitogen-activated kinases.
Salimgareeva MKh, Yamidanov RS, Vakhitova YV, et al. Bulletin of Experimental Biology and Medicine, 2012.
Effect of ladasten on the content of cytokine markers of inflammation and behavior of mice with experimental depression-like syndrome.
Tallerova AV, Kovalenko LP, Durnev AD, et al. Bulletin of Experimental Biology and Medicine, 2011.
The pharmacology of actoprotectors: practical application for improvement of mental and physical performance.
Oliynyk S, Oh S Biomolecules & Therapeutics, 2012.
Effects of bromantan on offspring maturation and development of reflexes.
Iezhitsa IN, Spasov AA, Bugaeva LI Neurotoxicology and Teratology, 2001.
This page is provided for research and educational reference only. It does not constitute medical advice, dosing guidance, or a recommendation for use. All compounds are strictly for laboratory and in-vitro research purposes.