Alpha GPC (L-alpha-glycerylphosphorylcholine, choline alphoscerate) is a choline-containing phospholipid derivative described as a precursor in the biosynthesis of brain phospholipids and as a cholinergic precursor that increases the availability of acetylcholine. Preclinical studies have examined hippocampal acetylcholine synthesis and release, cholinergic transporters and receptors, protein kinase C translocation and inflammatory markers in rat brain. It has also been examined in clinical research, including the ASCOMALVA trial.