Original pharmacological description
The compound was first reported in 1974 as 3-(2-benzylmethylamino ethyl) benzoic acid methyl ester hydrochloride, a novel spasmolytic and CNS active agent1.
Sources [1]
Neuroscience Research Compound · For laboratory research use only
PRL-8-53
- Formula
- C18H21NO2·HCl (C18H22ClNO2)
- CAS
- 51352-87-5 (hydrochloride)
Available as
Liquid
- 10mg/mL · 30mL$49.99
- 10mg × 30 units$24.99
- 10mg × 60 units$40.99
Certificates of analysis
Overview
PRL-8-53 is methyl 3-[2-[benzyl(methyl)amino]ethyl]benzoate, supplied as its hydrochloride salt. It was described in 1974 by Nikolaus Hansl as a spasmolytic and central nervous system active agent1.
Published research on PRL-8-53 is very limited. Beyond the 1974 description, the only indexed study is a 1978 double-blind study of verbal learning and retention from the same author2. No receptor binding, mechanistic, pharmacokinetic or toxicology studies have been identified on PubMed, and the work has not been independently replicated in the indexed literature.
Mechanism of action
As described in the research literature
As described in the research literature, the mechanism of action of PRL-8-53 has not been characterised. The 1974 paper describes it as a spasmolytic and CNS active agent1, but no receptor-level or pathway data have been published in indexed journals. Statements about cholinergic or other specific pathways should therefore be treated as unconfirmed.
Research areas
What published studies have examined
1978 verbal learning study design
A double-blind study used the serial anticipation method to examine acquisition and retention of verbal information, with visual reaction time and motor control as additional measures compared against placebo2.
Sources [2]
Evidence base and its limits
The indexed literature consists of these two papers by the originating author1,2. Researchers should be aware that there are no independent preclinical or replication studies on PubMed.
Specifications
- Molecular formula
- C18H21NO2·HCl (C18H22ClNO2)
- Molecular weight
- 319.8 g/mol (hydrochloride)
- CAS number
- 51352-87-5 (hydrochloride)
Liquid
- Form
- Pre-dissolved liquid at 10 mg/mL in a 30 mL bottle
- Storage
- Keep the bottle tightly closed, stored cool and away from direct light.
- Solubility and reconstitution
- Supplied ready to use: the liquid is pre-dissolved at 10 mg/mL, so no reconstitution is required.
Units
- Form
- Measured units with a stated amount per unit, 30 or 60 to a resealable foil pouch
- Storage
- Store in a cool, dry place in the sealed pouch, away from direct light.
- Solubility and reconstitution
- Supplied ready to use: each unit is pre-measured, so no reconstitution is required.
References
- 1
A novel spasmolytic and CNS active agent: 3-(2-benzylmethylamino ethyl) benzoic acid methyl ester hydrochloride.
Hansl NR Experientia, 1974.
- 2
PRL-8-53: enhanced learning and subsequent retention in humans as a result of low oral doses of new psychotropic agent.
Hansl NR, Mead BT Psychopharmacology, 1978.
This page is provided for research and educational reference only. It does not constitute medical advice, dosing guidance, or a recommendation for use. All compounds are strictly for laboratory and in-vitro research purposes.